Posted by SLS on January 27, 2008, at 5:10:12 [reposted on January 28, 2008, at 5:09:23 | original URL]
In reply to Re: Riluzole Lamictal questions, posted by kingcolon on January 26, 2008, at 23:31:17
Hi King.
Good catch!
> > My reading about riluzole seems to indicate that it is an antiglutamatergic agent, not a glutamate enhancer, similar to Lamictal. This is from the article below:
> "Consistent with a model of excessive glutamate-induced excitation in mood disorders, several antiglutamatergic agents, such as riluzole and lamotrigine, have demonstrated potential antidepressant efficacy."
> (From:http://www.ncbi.nlm.nih.gov/pubmed/16400244?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
You are absolutely right. Thanks for the correction. Riluzole seems to act as a glutamate uptake enhancer (opposite to an uptake inhibitor. Lamictal is a release inhibitor. Perhaps both would work synergistically if taken together.
- Scott
poster:SLS
thread:809296
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/809297.html