Posted by rgb on June 3, 2008, at 7:22:03
In reply to Re: What are some dopameric and/or noradrengeric med?, posted by undopaminergic on May 12, 2008, at 0:56:04
Sertraline is also somewhat dopaminergic; I seem to remember that its DAT affinity is roughly 1% of its SERT affinity. This doesn't sound all that bad (theoretically!) if you consider that SERT is saturated at low-ish doses and you don't need to nearly-saturate DAT.
With this in mind, I actually /increased/ my dose to 200mg and later to 300mg and on a few days even 400mg in an attempt to counter residual amotivation (don't try this at home.).
This even worked to some degree, though the increases felt more like a slight "awareness broadening" (5-HT2-esque) effect, no reinforcing/reward-type effect. Whatever it was, unfortunately I've mostly built tolerance to it and am mostly back in brain-fog-land. Go to 400mg permanently? (kidding ;)) My wild guess is that it's 5-HT2A downregulation; is there some way to counter this?
All of the above might be purely imaginary effects based on confirmation bias due to my neuroscience obsession, so take it with a major grain of salt please.
poster:rgb
thread:828365
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/832651.html