Posted by undopaminergic on June 6, 2008, at 7:58:40
In reply to PEA inhibits activity of DAergic neurons in VTA?, posted by iforgotmypassword on June 6, 2008, at 1:11:48
> huh?
>
> would this go against it being an opioid?Yes. PEA is definitely not an opioid.
> it is high in schizophrenia... unexpected contributor to negative symptoms?
>I think that if PEA is a significant factor in schizophrenia, it is more likely to play a role in worsening positive symtpoms, due to its amphetamine-like action - amphetamines are well-known to exacerbate positive schizophrenic symptoms, and may in fact provoke a temporary psychotic condition in high-dose users without pre-existing psychotic disorders.
> this goes against my idea of taking selegiline for neuroprotection... i find that more than a little disorienting. i want to prevent dopaminergic cell loss...
>Selegiline's neuroprotective actions are in part due to its inhibition of oxidative metabolism by MAO-B, and in part due to antioxidative and/or other neuroprotective properties of selegiline itself, or more likely, its desmethylselegiline metabolite. It's my impression that rasagiline is an even more potent agent for this purpose.
poster:undopaminergic
thread:833235
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/833257.html