Posted by SLS on July 28, 2008, at 17:57:08
In reply to MAOI-TCA combos » SLS, posted by Crotale on July 27, 2008, at 14:09:17
> > Minalcipran. SNRI. I believe it is being investigated as a treatment for fibromyalgia and other pain disorders.
> I forgot to ask something (this has been confusing me on this board for a while): does "SNRI" = "selective norepinephrine reuptake inhibitor" [like Strattera] or "serotonin/norepinephrine reuptake inhibitor" [like Effexor]?The answer is both...
The acronymn, "SNRI", was originally used to denote a selective norepinephrine reuptake inhibitor. I believe it came into use around the time viloxazine, reboxetine and atomoxetine were first referred to as such. Later, "SNRI" came to mean serotonin/norepinephrine reuptake inhibitor of which there are three representatives: Effexor, Pristiq, and Cymbalta.
> And what would you call the other one, then?"NARI" has since come to mean noradrenergic reuptake inhibitor.
"SRI" = serotonin reuptake inhibitor (in addition to other properties).
> > Imipramine definitely produced serotonin syndrome when I added it to Nardil.
> You mixed imipramine with Nardil?Yes. My condition was extremely resistent to monotherapy. It only took doctors and me 26 years to find a treatment that produced a robust antidepressant response.
:-/
> Scott, I forgot to mention this: you have really gigantic balls. At least, in the metaphorical sense.
I was desperate. I even took a single dose of Effexor while taking Parnate to see for myself if a SRI would cause SS when combined with a MAOI. The answer is yes. It only took 45 minutes to emerge. I was completely incoherent and couldn't stand up. My muscles tensed up and made it impossible to get out of bed. Luckily, the reaction lasted for only an hour or so. Parnate + imipramine was without ill effect, whereas Nardil + imipramine produced moderate SS.
> (I got CSS just from taking Cymbalta. No risky mixtures required.)
You'll here of this occasionally, where SS will be produced by SRI monotherapy.
One day, medical science will provide us with ways to choose certain drugs and reject others based upon gene activity and PET scans. Until then, don't give up on using clinical trial-and-error algorithms. I don't expect you will need to wait 26 years to achieve remission.
By the way, my current treatment consists of:
nortriptyline 150mg
Nardil 90mg
Lamictal 200mg
Abilify 20mg
Deplin 7.5mg
N-acetylcysteine 1800mg
- Scott
poster:SLS
thread:829828
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/842653.html