Posted by Questionmark on August 7, 2008, at 1:11:41
In reply to Re: Is Mirtazapine really a NaSSA?, posted by dbc on July 26, 2008, at 11:57:32
It blocks 5-HT1A, 5-HT2A and 5-HT3 receptors i believe. But antagonism of 5ht1A receptors causes enhanced release of serotonin. Therefore it is claimed to promote serotonin transmission and yet block some of the receptors associated with some of the serotonergic side effects.
As a NE alpha-2 antagonist, it works in a similar way with norepinephrine as well, promoting its release in many areas.
> Its been found to have some serotongenic promoting properties but they have no idea why or how. I assume enough rats died with higher levels of serotonin and they decided it promoted serotonin.
poster:Questionmark
thread:841595
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/844743.html