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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by linkadge on June 19, 2005, at 20:38:45
Migraine has numerous relationships to endocannabinoid function. Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment.
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http://www.marijuanapassion.com/forum/archive/index.php/t-166.html
This might also lead to it's anxiolitic/antidepressant activity
Linkadge
Posted by Spriggy on June 19, 2005, at 22:54:40
In reply to Marajuanna, chocolate, exercise = anandamide, posted by linkadge on June 19, 2005, at 20:38:45
Okay... I can go for the whole chocolate thing (big time... I'm sold) and on a good day, I can go for the exercise thing.. but the marijuana thing.. not so sure. ROFL
Posted by Chairman_MAO on June 20, 2005, at 15:33:10
In reply to Marajuanna, chocolate, exercise = anandamide, posted by linkadge on June 19, 2005, at 20:38:45
You would have to eat kilos of chocolate to get enough ananadamide to produce any effect at all. Moreover, it is rapidly degraded by FAAH, so the oral route is usually not considered feasible, even with PURE anandamide.
Posted by linkadge on June 20, 2005, at 17:02:11
In reply to Re: Marajuanna, chocolate, exercise = anandamide » linkadge, posted by Chairman_MAO on June 20, 2005, at 15:33:10
Not necessarily, chocolate also contains compounds that inhibit the metabolism of anandamide. A study (I cannot find right now) showed that anandamide binding was insignificant with milk chocolate but present with dark chocolate.
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http://panicdisorder.about.com/cs/shfitness/a/chocolate.htm
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the first study also found that chocolate also contains n-acylethanolamines which may preserve the brain's natural anandamine, thereby extending any uplifting effects from the chocolate's anandamide.
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I buy a bar of bakers chocolate and then eat it when going for a run. I had a single puff of marajuanna the other night, and I said to myself, this is a similar feeling. Things go very bright, and my vision became very crisp. The bright vision effect doesn't happen till 30+ minuates jogging.There are of course many other factors at play.
Linkadge
Posted by Jakeman on June 20, 2005, at 19:27:34
In reply to Marajuanna, chocolate, exercise = anandamide, posted by linkadge on June 19, 2005, at 20:38:45
I'd say take dark chocolate and a toke at each water break.
http://www.dr-bob.org/babble/alter/20050101/msgs/436411.html
~J
Posted by Chairman_MAO on June 21, 2005, at 11:59:10
In reply to Re: Marajuanna, chocolate, exercise = anandamide, posted by linkadge on June 20, 2005, at 17:02:11
Are you still using fo-ti? If so, that "brightness" feeling you are describing could very well be the result of PEA intake, not anything cannabinamimetic. I am interested in your claims about chocolate; please show me peer-reviewed evidence that intake of [dark, light, whatever] chocolate can cause a significant effect on cannabinoid receptors.
Posted by linkadge on June 21, 2005, at 20:29:11
In reply to Re: Marajuanna, chocolate, exercise = anandamide » linkadge, posted by Chairman_MAO on June 21, 2005, at 11:59:10
Yes, it is quite possable that the effect is more to do the PEA actions of Fo-Ti, exercise, and chocolate.
I read a lot of studies. I will see if I can find the one I was referring to. While I don't think it meets your critera, I believe it did show that dark chocolate intake was associated with detectable changes in anandamide activity. You've never heard the term "stoned chocoholics" ??
Linkadge
Posted by Chairman_MAO on June 22, 2005, at 16:02:50
In reply to Re: Marajuanna, chocolate, exercise = anandamide, posted by linkadge on June 21, 2005, at 20:29:11
Cannabinoid mimics in chocolate
utilized as an argument in court
by
Tytgat J, Van Boven M, Daenens P
Laboratory of Toxicology,
E, Leuven, Belgium.
jan.tytgat@farm.kuleuven.ac.be
Int J Legal Med 2000; 113(3):137-9ABSTRACT
A case is presented involving chocolate cannabinoid mimics which have been utilized in court by the defendant's lawyer in order to clear the accused of smoking and dealing in marijuana after he was found positive for cannabis in a routine urine immunoassay screening test. The argumentation in this case was that the accused had supposedly eaten a massive amount of chocolate which contained anandamide-related lipids. These lipids inhibit anandamide hydrolysis in the brain, act as cannabinoid mimics and, according to the lawyer, were the cause of the positive cannabinoid test. To investigate this in detail, we synthesized N-oleoyl- and N-linoleoylethanolamide and spiked these compounds together with N-arachidonoylethanolamide in urine for immunological investigations. None of the samples were found positive, indicating that no cross-reactivity occurs with cannabinoids. As a result, the lawyer's claim could be refuted and the accused was convicted.
Posted by linkadge on June 22, 2005, at 17:56:56
In reply to Re: Marajuanna, chocolate, exercise = anandamide » linkadge, posted by Chairman_MAO on June 22, 2005, at 16:02:50
Yeah, I read that study, and suspected you might come across it. It doesn't really support my case does it.
The study I am looking for I believe I found on the LEF website somewhere. Done in some European region. It just said something about how the long time chocolate eaters vs. noneaters had detectable alterations in anandamide activity.
Linkadge
Posted by Chairman_MAO on June 23, 2005, at 10:36:43
In reply to Re: Marajuanna, chocolate, exercise = anandamide, posted by linkadge on June 22, 2005, at 17:56:56
Could this alteration simply be the psychobiological substrates of the chocolate-eating experience? After all, the cannabinoid system obviously is involved in the experience of eating delicious food (CB1 receptors regulate leptin, as well). Think of it this way: psychotherapy has been shown to produce some of the same changes in the brain as AD treatment does. Does this mean that psychotherapy is psychoactive like a drug? Yes and no. The message: there is a neuropsychobiological substrate for every state of consciousness.
Posted by linkadge on June 23, 2005, at 15:57:10
In reply to Re: Marajuanna, chocolate, exercise = anandamide » linkadge, posted by Chairman_MAO on June 23, 2005, at 10:36:43
This is entirely possable.
Linkadge
This is the end of the thread.
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