Posted by Brainbeard on February 10, 2010, at 16:41:42 [reposted on February 21, 2010, at 13:24:08 | original URL]
In reply to Fluoxetine(prozac) is a 5-HT2A antagonist., posted by conundrum on February 10, 2010, at 12:24:34
Great link, by the way. The R-isomer of fluoxetine seems superior. But what do you know?
'Eli Lilly and Company halted development of the R- isomer of fluoxetine (Prozac) after Stage III clinical trials revealed unexpected cardiac side effects (Psychiatric News, December 1, 2000). The company had hoped that R-fluoxetine would replace fluoxetine, which was facing imminent expiration of its patent protection.'
(http://pn.psychiatryonline.org/content/36/24/17.3.full)
Cardiac side-effects.. How bad??!! A little tachycardia? Sudden deaths from heart failure? I hope it was bad enough to justify leaving this wonderful isomer behind.
It seems a company called Sepracor has investigated the use of the isolated S-isomer for migraines. Don't know where that went.
poster:Brainbeard
thread:937575
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/937577.html